Ozempic Vs. Metformin: Which is Best for You?

Published by Health Professional

on Sunday, March 26th 2023

DiabetesWeight Control

When it comes to managing type 2 diabetes, many medications are available on the market. Two of the most popular options are Ozempic and Metformin. 

While both medications can help lower blood sugar levels, they work in different ways and have advantages and disadvantages. In this article, we’ll take a closer look at Ozempic and Metformin and compare them to help you decide which medication may be best for you.

Understanding Type 2 Diabetes

Before we delve into the specifics of Ozempic and Metformin, it’s important to have a basic understanding of type 2 diabetes. This chronic condition affects how your body processes blood sugar (glucose). 

If left untreated, high blood sugar levels can cause a host of health problems, including heart disease, stroke, kidney disease, and nerve damage.

Type 2 diabetes is often managed through lifestyle changes, such as exercise and diet modifications. However, medications are also commonly prescribed to help control blood sugar levels. These medications can be taken orally or through injections.

What is Ozempic?

Ozempic is a brand-name prescription medication that contains the active ingredient Semaglutide. It is a once-weekly injectable medication that helps to lower blood sugar levels by mimicking the effects of the hormone GLP-1. GLP-1 helps to regulate blood sugar levels by stimulating insulin release and suppressing glucagon secretion.

In addition to its blood sugar-lowering effects, Ozempic has also been shown to help with weight loss. This is because it helps to reduce appetite and slow down digestion. Ozempic is typically prescribed in conjunction with diet and exercise modifications.

What is Metformin?

Metformin is a generic medication available in both immediate-release and extended-release formulations. It is an oral medication that works by reducing the amount of glucose produced by the liver and improving insulin sensitivity. 

This helps to lower blood sugar levels and reduce the risk of complications associated with type 2 diabetes.

In addition to its blood sugar-lowering effects, Metformin has also been shown to benefit weight loss and heart health. It is often prescribed as a first-line medication for type 2 diabetes and is typically taken twice daily with meals.

Comparing Ozempic and Metformin

When it comes to choosing between Ozempic and Metformin, there are several factors to consider. Here are some of the key differences between the two medications:

Method of Administration

One of the most obvious differences between Ozempic and Metformin is how they are administered. Ozempic is a once-weekly injection, while Metformin is taken orally and can be taken multiple times daily.

Blood Sugar Control

Both Ozempic and Metformin are effective at lowering blood sugar levels. However, Ozempic tends to be more effective than Metformin in reducing HbA1c levels. HbA1c is a marker of long-term blood sugar control.

Weight Loss

Both medications have been shown to have benefits for weight loss. Ozempic is more effective at weight loss than Metformin. However, weight loss is not a primary indication for either medication.

Side Effects

Both Ozempic and Metformin can cause side effects. The most common side effects of Ozempic are nausea, diarrhea, and constipation. 

Metformin’s most common side effects are nausea, diarrhea, and abdominal pain. However, these side effects are generally mild and tend to subside over time.


Cost is another important factor to consider when choosing between Ozempic and Metformin. Ozempic tends to be more

expensive than Metformin, although the exact cost can vary depending on your insurance coverage and location.

Which Medication is Best for You?

The decision between Ozempic and Metformin ultimately comes down to individual preferences and circumstances. Here are some factors to consider when choosing between the two medications:

  • Method of Administration: Metformin may be the better option for you if you fear needles or prefer oral medications. 
  • However, if you have difficulty remembering to take medication multiple times daily, Ozempic’s once-weekly injection may be more convenient.
  • Blood Sugar Control: If you have uncontrolled blood sugar levels or high HbA1c levels, Ozempic may be the better option for you. 
  • However, Metformin may be sufficient if your blood sugar levels are relatively stable.
  • Weight Loss: If you are overweight or obese and struggle with blood sugar control, Ozempic may be a better choice due to its additional weight loss benefits. 
  • However, if weight loss is not a primary concern, Metformin may be sufficient.
  • Side Effects: Metformin may be the better option for you if you have a history of gastrointestinal issues or are particularly sensitive to medication side effects. 
  • However, Ozempic may be a viable option if you are generally healthy and tolerating the medication well.
  • Cost: If cost is a major concern for you, Metformin is the better option as it is less expensive than Ozempic.

Ultimately, it’s important to discuss your options with your healthcare provider to determine which medication is best for you.


Ozempic and Metformin are two popular medications used to manage type 2 diabetes. While both medications can help lower blood sugar levels, they have different mechanisms of action and come with advantages and disadvantages. 

By understanding the differences between the two medications and considering your circumstances, you can decide which medication is best for you.


Is Ozempic better than Metformin for weight loss?

  1. While both medications can help with weight loss, Ozempic tends to be more effective than Metformin.

Can I take Ozempic and Metformin together?

  1. Yes, Ozempic and Metformin can be taken together. In fact, they may be prescribed together to help improve blood sugar control.

Are there any long-term side effects of Ozempic or Metformin?

  1. Both medications are generally considered safe and well-tolerated. However, as with any medication, there is a risk of side effects with long-term use.

Can Ozempic be taken once a month instead of once a week?

  1. No, Ozempic is only intended to be taken once a week. Taking it less frequently may reduce its effectiveness.

Can Metformin cause low blood sugar?

  1. While Metformin is not known to cause low blood sugar (hypoglycemia), it can increase the risk of hypoglycemia when combined with other diabetes medications.